ABSTRACT
Background: Colocasia gigantea is an erect herbaceous perennial tropical root crop of the family Aracea,
produced majorly for its underground corms. It is locally called ‘ede nwokuko’ or kochu because of its
believed healing power to cure several illnesses. The aim of the research work is to determine the effect of
chronic administration of methanolic leaf extract of Colocasia gigantea on the liver enzymes of Adult Male
Wistar Rats.
Methods: Twenty 20 male wistar rats were randomly grouped into four groups of five animals each (n=5)
which weighed 160 – 199 gram. Group A, served as control received water and feed throughout the
experiment only. Group B, Group C, and Group D received oral administration of 100mg/kg, 250mg/kg and
500mg/kg of methanolic leaf extract, of Colocasia gigantea respectively. The administration lasted for
90days.
Results: Findings showed statistically significant increase in the liver enzymes; Aspartate Transaminase, and
Alanine Transaminase in groups B, C and D, compared to the control group A. There was also a statistically
significant increase in the enzyme, Alkaline Phosphatase show in groups B, C, only compared to group A.
Conclusion: The chronic adminstration of methanolic leaf extract of Colocasia gigantea on adult male
wistar rats, showed statistically significant increase in liver enzymes; Aspartate Transaminase, Alanine
Transaminase and Alkaline Phosphatase.
Key words: Colocasia gigantea, liver enzymes, adult male wistar rats
CITE THIS ARTICLE: Enemuo EH, Enemuo IC, Ezejindu DN, Enemchukwu O, Enemchukwu E; Effect
of Chronic Administration of Methanolic Leaf Extract of Colocasia Gigantea on Liver Enzymes of Adult
Male Wistar Rats. Global Professionals Multidisciplinary Practices Journal. 2024, 1(2): 31-40
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