ABSTRACT
Investigation of moringa oleifera administration on pain behaviour was experimented for six weeks with
albino mice weighing 12-33 grams. They were randomly grouped into 3 of 5 mice each. Two test groups
were treated with moringa oleifera but one was discontinued (representing withdrawal), while a control
group had no moringa administered. After administration, rodents were exposed to pain by hot plate test
where their response to pain was recorded, analysed and interpreted accordingly using standard methods.
The result showed that mice treated with Moringa and subjected to withdrawal exhibit significantly
higher (9.54±1.71) pain tolerance compared to Moringa- treated mice without withdrawal (5.06±0.66) ;
although non-treated mice had relatively higher (10.06 ± 0.22) pain tolerance than the two moringa
groups. It appears Moringa oleifera may have lasting analgesic effect even after cessation of treatment.
Perhaps more research to elucidate the mechanisms underlying analgesic activity of moringa oleifera and
its potential as a long-term pain management regimen may be worthwhile.
Key words: Pain, moringa oleifera, mice, analgesic, withdrawal
How to cite: Joffa PPK.1, Potts-Johnson G. 1, Orluwosu JC. 1, Erigbali P.P.1 . Evaluation of Impact of Moringa
Oleifera Administration and Withdrawal On Pain Tolerance in Experimental Mice Model. Global
Professionals Multidisciplinary Practices Journal. 2025, 1(5):32-38
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